Following the road of the well-known SEEG courses, we wish to open additional ways looking especially to the PET in the non-invasive presurgical work-up for drug resistant focal epilepsy. We are proud to announce the 1st International PET course will be held at the CEA (Atomic Energy Commission), in Orsay, near Paris, May 31 to June 2, 2017
- Both PET and MRI are usually obtained in most epilepsy surgery centers. Co-registration of 18F-FDG PET with MRI has proved its additional value to improve the detection of epileptogenic lesions and there is strong evidence supporting favorable surgical outcome in patients with negative MR - positive PET. In addition, PET findings may help the implantation strategy when invasive recordings such SEEG are needed. Best identification of PET abnormalities would refine the definition of the epileptogenic zone by optimizing the cortical sampling. However, the accuracy of PET and MRI superimposition may vary according to the software that is used. Visual analysis of PET imaging is challenged by the experience of the reader. Small lesions may be missed in extratemporal areas whereas false positive may also be done. On the other hand, statistical analysis processes are helpful but are not available in clinical practice. All these limits play a role in the apparently low sensitivity of PET and restrain its interest in epilepsy surgery.
- Based on a large experience in adult and children PET imaging correlated with SEEG and epilepsy surgery, we aim to share our knowledge with neurologists, neurosurgeons and nuclear physicians who want to optimize the use of PET in surgical planning. During this course specially dedicated to the integration of PET in presurgical investigations, we will discuss the best tools for the detection of relevant abnormalities regarding the epileptogenic zone and the cortical resection planning. For that we will demonstrate the respective role of visual analysis with and without MR coregistration and the value of statistical analysis using statistical analysis mapping (SPM). Precise correlations with SEEG and histological data in individual cases will be presented. We will also discuss the particular aspects of PET in children epilepsy and the new advanced techniques based on PET-MRI.
- Computer-assisted practical training will be conducted in small groups led by experienced tutors, demonstrating the different analysis techniques in surgical patients in whom the PET has played a key role. State of the art lectures will complete this first international course of PET in Epilepsy.
You will find attached a preliminary program
This course will be limited to 30 participants.
With our best regards
On behalf of Francine Chassoux, Catherine Chiron, Philippe Ryvlin
Co-directors of the course